Thomas Tuchel has made three changes from the team that begun the win against Porto midweek.
There is no Andreas Christensen due to injury and Thiago Silva is suspended following his red card against West Brom, so Kurt Zouma comes into the side.
Callum Hudson-Odoi is in for Reece James and Christian Pulisic replaces Timo Werner in the front line.
Crystal Palace are unchanged so former Blues Gary Cahill and Patrick van Aanholt start. Michy Batshuayi, on loan from Chelsea, is ineligible.
Chelsea: Mendy; Azpilicueta (c), Zouma, Rudiger; Hudson-Odoi, Jorginho, Kovacic, Chilwell; Pulisic, Havertz, Mount.
Subs: Kepa, Alonso, Emerson, James, Kante, Ziyech, Abraham, Giroud, Werner.
Palace: Guaita; Ward, Kouyate, Cahill, Van Aanholt; Ayew, Milivojevic (c), Riedewald, Eze; Benteke, Zaha.
Subs: Butland, Dann, Kelly, Mitchell, McCarthy, Schlupp, Townsend, Rak-Sakyi, Mateta.
The referee is Michael Oliver.